Conference Overview 

ELRIG (European Laboratory and Robotics Interest Group), SLAS the (Society for Laboratory Automation and Screening) and BPS (British Pharmacological Society) are now preparing for the Fifth Annual Drug Discovery Conference to be held at Manchester Central on 7^th & 8^th September 2011.

As in previous years the objective of this conference is to provide a communication, education and networking opportunity for scientists engaged in early-phase drug discovery whether in academia, biotech or industry. As with our highly successful meeting in 2010, attendees will hear world class speakers discussing the challenges and opportunities facing the drug discovery scientist. The scientific sessions will be complemented by a large poster session, a growing vendor exhibition with over 85 exhibitors and a number of training sessions.

Delegates: Click here to register for free

Click here for exhibitor booking

Additional delegate information is available here

 

As in previous years the objective of this conference is to provide a communication, education and networking opportunity for scientists engaged in early-phase drug discovery whether in academia, biotech or industry. As with our highly successful meeting in 2010, attendees will hear world class speakers discussing the challenges and opportunities facing the drug discovery scientist. The scientific sessions will be complemented by a large poster session, a growing vendor exhibition with over 85 exhibitors and a number of training sessions.

In 2011 the Drug Discovery Symposium will encompass Eight Scientific Sessions.    Hover over the Session to Read the Synopsis.

DAY 1

GPCR Drug Discovery

Assay Development and Screening

Biological Sample Management

Safety Profiling in Early Discovery

 

DAY 2

Enzyme Drug Discovery

Robotics and Automation

Cellular Imaging Technologies

Cell Systems for Drug Discovery

We invite all members of the drug discovery community to attend the Drug Discovery meeting in 2011.   There will be over 100 Vendor Trade Stands and this is set to be the largest Drug Discovery Event for 2011 – put the dates in your Diary –   7 & 8th September 2011

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Liquid Handling Bootcamps and Workshops :  Hands on Laboratory Robotics

Course details:

http://lnk.ie/4HJ6/e=!*EMAIL*!/http://www.automationtrainer.com/eulhworkshop.html

 

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SPEAKER PROGRAMME:

 

DAY 1	GPCR Drug Discovery SESSION 1	Assay Development and Screening SESSION 2	Biological Sample Management SESSION 3	Safety Profiling in Early Discovery SESSION 4
9.00 - 9.15 Session Chair Introductions	Graeme Milligan, Glasgow  Steve Garland	Richard Eglen, Corning Jeff Paslay	Glyn Stacey, UN Stem Cell Jonathan Wingfield, AZ	Julie Holder, GSK Laszlo Urban, Novartis
9.15 – 10.00	Bitter Taste Receptors on Airway Smooth Muscle Couple to a Restricted Ca2+ Pool and their Agonists are Highly Efficacious Bronchodilators Stephen Liggett, Maryland Uni	High throughput screening and assay development - fit for purpose?   Richard Eglen, Corning	Management of Stem Cells within the Biobanking Industry Pasquale de Blasio, ESBB & BioRep	High Content Analysis of Cytotoxity for Prediction, Mechanistic Elucidation and Blood Biomarkers of Human Toxicity Peter O'Brien, UCD
10.00 – 1.0.30	Olodaterol: a novel ß2 agonist with once daily potential. Possible rationales for long duration of action Paola Casarosa, Boehringer-Ingleheim	High Throughput Screening: Historical Success and Future Perspectives Steve Rees, AstraZeneca	Considerations in the Management of the finite UK Biobank sample resource to maximise its scientific research utility Paul Downey, UK BioBank	Progress and challenges of automating culture of human pluripotent stem cells Chris Denning, Nottingham Uni
10.30 – 11.00	COFFEE BREAK	COFFEE BREAK	COFFEE BREAK	COFFEE BREAK
11.00 – 11.30	Pharmacological Chaperones: Potential Therapeutic approach to treat MC4R-Linked early onset obesity? Patricia Rene, Montreal Uni	Microfluidics Enables Small-Scale Tissue-Based Metabolism Studies using Human and Rat Precision-Cut Tissue Slices Paul van Midwoud, Groningen Uni	Human sample biorepositories and infrastructure to enable drug discovery at AstraZeneca Chris Womack, AZ	Moving attrition.   Easier said than done?     The case for early genetic toxicology prediction Steve Beasley, Gentronix
11.30 – 12.00	Developing Novel Ligends for Free Fatty Acid Receptors Graeme Milligan, Glasgow University	Early experiences with the Dynaflow HT, a microfluidics-based multichannel automated electrophysiology platform Gary Clark, BioFocus	Establishing a regional multi-centre Cancer BioBank Jane Rogan, MCRC BioBank	Mouse Embryonic Stem Cell Derived Cardiomyocytes and the RTCA Cardio Instrument - The Perfect Match for Screening Cardiac Effects   Kristina Tressat, Axiogenesis
12.00 – 12.30	SNAPSHOTS Cellectis, CellAura, Vectalys, Aurelia Bio	SNAPSHOTS Ziath, Nanion, TTP, The Research Network, BMG, Beckman Coulter	From Biological Sample to Genetic Loci: Automating Large-Scale Epidemiological Research Matt Sims, MRC Cambridge	SNAPSHOTS Roche, Zyoxel, TechGen, Cisbio
12.30    - 2.30	LUNCH/POSTER VIEWING	EXHIBITION	LUNCH/POSTER VIEWING	EXHIBITION
2.30    - 3.00	Can the phosphorylation profile of GPCRs drive functionality? Andrew Tobin, Leicester Uni	Enabling Lead Discovery at Epigenetics Targets with RapidFire™ Mass Spectrometry Stuart Baddeley, GSK	Circulating Tumor Cells the Grand Challenge……. and a tentative solution Christer Ericsson, Karolinska Institute	Early safety assessment of drug candidates: Utility of in vitro pharmacological profiling Laszlo Urban, Novartis
3.00 – 3.30	GPCR biased ligands; from theory to practice Conrad Cowan, Trevena	Label free primary screening of 7TMRs – a superior approach to identify agonists and PAMs ? Frank Stuhmeier, Pfizer	Biobanking of gametes, embryos and reproductive tissues: preserving and extending fertility Daniel Brison, NW Embrionic SCC	In Vitro Safety Profiling During Lead Optimisation Murray Brown, GSK
3.30 - 4.00	Discovery of selective S1P1 agonists efficacious at low oral dose and devoid of adverse cardiovascular signal James Bailey, GSK	HTS Approaches To Epigenetics Helen Boyd, Pfizer	Bio-Banking of Adult Stem Cells Mike Byrom, BioEden	Multi-parameter Optimisation in Drug Discovery: Quickly targeting compounds with a good balance of properties Matthew Segall, Optibrium
4.00 – 5.00	POSTER AWARDS	POSTER AWARDS	POSTER AWARDS	POSTER AWARDS
5.00 – 7.00	DRINKS RECEPTION IN THE	EXHIBITION HALL

DAY 2	Enzyme Drug Discovery SESSION 1	Robotics and Automation SESSION 2	Cellular Imaging Technologies SESSION 3	Cell Systems for Drug Discovery SESSION 4
8.30 - 8.45 Session Chair Introductions	David Gray, Dundee Uni Catherine Kettleborough, MRC Technology	Andy Zaayenga, High Res Colin Bath, AstraZeneca 8.25 - 8.30	Stephen Hill, Nottingham Uni Rod Benson, Imagen Biotech	Mike Jowett Katy Gearing, GSK
8.45 – 9.30	Chemistry driven target selection  Richard Bickerton, Dundee Uni	8.30-9.00 Development of an Automated Frozen Sample Aliquotter Dale Larson, CryoXtract 9.00-9.30 The Italian Chemical Collection and Screening Initiative: setting up strategies and automation Alberto Bresciani, IRBM	Application of systems biology approaches to study cell signalling and transcription Mike White, Manchester Uni	Induced Pluripotent derived terminal tissues for drug discovery and development: An industrialized approach Chris Kendrick-Parker, Cellular Dynamics
9.30 – 10.00	Identifying the first inhibitors of rhomboid intramembrane proteases Matthew Freeman, MRC	High Throughput qPCR Gene Expression Screening Enabled by Nanofluidic Droplets Tara Dalton, Life Tech	Configuration of mechanistic high content imaging assays for histone demethylases Roy Katso, GSK	Patient-relevant disease models for targeted drug discovery and cell-based screening applications Chris Torrance, Horizon Discovery
10.00 – 10.30	DNA damage response (DDR) enzymes as therapeutic targets in oncology Alan Lau, AstraZeneca	Implementation of Automated Cell Culture and Cell Assay Platforms within the University of Manchester Centre of Excellence in Biopharmaceuticals Annes Lambert, Manchester Uni	High-content analysis of signalling networks using protein fragment complementation assays (PCA) Anthony Pitt, Lonza	Rapid, Multi-Well Fabrication of Living 3D-Tissue Models  for Testing & Controlled Release Robert Brown, UCL
10.30 – 11.00	SNAPSHOTS Scottish BioMed, Assaymetrics, Ubiquigent	SNAPSHOTS Hamilton, Cybio, Agilent, Caliper, Photophysics, High Res	SNAPSHOTS Beckman Coulter, Imagen Bio, PerkinElmer, Essen Bio	SNAPSHOTS Corning, Stem Cell Tech, Maxcyte, InSphero
11.00 – 11.30 11.30 - 12.20	COFFEE BREAK KEYNOTE:	COFFEE BREAK Current State of Induced Pluripotent Stem cells as compared to Embryonic Stem cells and their role in creating terminal tissue models	COFFEE BREAK   Jamie Thomson Wisconsin University	COFFEE BREAK
12.20 – 1.45	LUNCH/POSTER VIEWING	EXHIBITION	LUNCH/POSTER VIEWING	EXHIBITION
1.45 - 2.15	Fragment Based Drug Discovery in Academia and Biotech Tom Heightman, Astex Therapeutics	Accelerated Discovery of Single Cells and Biomolecules using Automated Picodroplet Systems Frank Craig, Sphere Fluidics	A Quantitative Plate-Based Assay to Screen for Changes in Gene Expression within Pain Pathways of Primary Rat Sensory Neurons Darren Cawkill, Pfizer	Miniturising the Laboratory in Droplets Andrew Griffiths, Stratzbourg University
2.15  - 2.45	The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis James Leiper, Imperial College	Implementation of an automated 'Cell based Combination' platform Eric Tang, AstraZeneca	G-Protein Coupled Receptor Heteromers and Drug Discovery Kevin Pfleger, Dimerix	Human primary cell based assays – a challenge but worth it in the end! Caroline Freathy, Asterand
2.45 – 3.15	Structure-based studies on the inhibition of a DNA supercoiling machine Benjamin Bax, GSK	An automated integrated approach for SAR generation Dave Parry, Cyclofluidic	Fluorescence based live cell binding assays for GPCRs  Leigh Stoddart, Nottingham Uni	Primary Cells in Screening Angela Dunne, GSK
3.15 - 3.45	COFFEE BREAK	COFFEE BREAK	COFFEE BREAK	COFFEE BREAK
3.45 – 5.00	CLOSING DEBATE:   Chris Lipinski, Melior Discovery Kevin Johnson, Index Ventures	THE FUTURE OF DRUG        DISCOVERY:   Advocating Small Molecules Advocating Biopharmaceuticals	Small Molecules & Biopharmaceuticals

 

LONZA LUNCHTIME WORKSHOPS  

Wednesday 7th                                                               

12.35 - 13.25                                                                   

Pathway Selectivity Profiling Using NodeSensor PCA techology       -       Anthony Pitt

13.25 - 14.15

Strategies for Primary and Stem Cell supply in Discovery               -       Alex Batchelor      

Thursday 8th

12.25 - 13.15        

Measuring Calcium and cAMP Signalling from Endogenous Targets in Primary Cells      -    Anthony Pitt

Registration at ELRIG Registration desk, Lonza stand A3 or at  www.lonza.com/elrig-dd2011

 

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Posters      -       To Send in a Poster Abstract please go to:   This e-mail address is being protected from spambots. You need JavaScript enabled to view it .  Deadline 26th August 2011.

Poster Board Sizes:   H = 1.80      W= 1.50

SLAS Young Scientist Award

Students, graduates and post-docs are welcome to compete for the SLAS Young Scientist Award at the ELRIG Drug Discovery 2011 Annual Conference and Exhibition, September 7-8, at Manchester Central, United Kingdom.

The winner will be invited to present and participate in the Student Poster Competition at the 1^st Annual SLAS Conference and Exhibition, February 4-8, 2012, at the San Diego Convention Center, San Diego, CA, USA.  SLAS Young Scientist Award winners receive a $500 cash prize, roundtrip coach airfare, shared hotel accommodations and conference registration for SLAS2012.

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Innovation Zone  -   New Technology Companies   -   To apply for the Innovation Zone contact:

This e-mail address is being protected from spambots. You need JavaScript enabled to view it

InSCREENeX GmbH

Venomtech Ltd

Zyoxel Ltd

Semba Biosciences

The Research Network

Flexible Lab Solutions

Amebis

CryoGaTT

Ubiquigent

Imagen Biotech

INTAVIS Bioanalytical Instruments

 

EXHIBITOR LIST 

4titude Ltd Affymetrix Agilent Technologies Almac Group AlphaBiotech Ltd Applied Photophysics Ltd Assaymetrics Limited Astech Projects Aurelia Bioscience Beckman Coulter Bigneat Containment Technology Biocair BioFocus BioTek Instruments Limited BMG Labtech Caliper Life Sciences Ltd Caltag Medsystems Ltd Cambridge Bioscience CCS Cell Culture Service CellAura Technologies Ltd Cellectis Bioresearch Cisbio Bioassys Computype Contained Air Solutions Limited

Corning Life Sciences CyBio Northern Europe Ltd Dotmatics Enzo Life Sciences (UK) Ltd Eppendorf UK Essen BioScience Ltd FluidX Genetix Ltd Genevac Gentronix Limited Greiner Bio-One Hamamatsu Photonics UK Ltd Hamilton Robotics Ltd Highres Biosolutions HPA Culture Collections INNOPROT InSphero AG Integrated DNA Technologies Intellicyt Corporation Kbiosystems/Wildcat Laboratory Solutions Labcyte Inc Laboratory Consumable Supplies Ltd (LCS) Liconic UK Ltd Life Technologies

Lonza MaxCyte Merck Millipore Molecular Devices MRC Technology Nanion Technologies GmbH NEXUS Biosystems AG PerkinElmer PharmaDiagnostics Promega UK Ltd ReTiSoft Inc Roche Diagnostics Limited RTS Life Sciences Scottish Biomedical Sigma-Aldrich Sirius Analytical Stemcell Technolgoes TAP Biosystems Tecan UK Ltd Thermo Fisher Scientific Titian Software Ltd TTP Labtech Vectalys Ziath Ltd Zinsser Analytic UK Ltd

 

Vendor Exhibition Trade Show:    

Click here for exhibitor booking

Click here for free delegate registration

 

 

Delegates can register and attend the event, Free of Charge

 

 

SPONSORS:

Media Sponsors:

 

 

HOTEL BOOKINGS:

 

Conference Hotel:   Premier Inn, Manchester Central   -  Premier Inn Group Enquiries   Tel: 0871 527 9253      

If you would like to stay in the same Hotel as the ELRIG staff, Speakers etc then you can book through the above number, alternatively go to the Hotel List and choose from there to suit your budget.

 

Manchester University Accommodation:

If you are on a strict budget, but would like to attend the Drug Discovery Meeting, we have secured En-Suite and Standard Rooms at Manchester University.

CLICK the link to go through to their booking form.   Attend and Stay for much less:  https://www.meeting.co.uk/confercare/elrig2011

Hotels in Manchester City Centre:

For the List of Manchester Hotels available and giving ELRIG preferential rates - Click the link, choose and book your accommodation:

https://www.conferencebookings.co.uk/delegate/MNCELRIG2011

 

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