Therapeutic Oligonucleotides 2025

Drugging The Undruggable

Free-to-attend!

Date

14 – 15 May 2025

Location

Gothenburg, SE

Day(s)

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Hour(s)

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Minute(s)

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Event Overview

The second ELRIG meeting on Therapeutic Oligonucleotides, scheduled for May 14-15, 2025, will be hosted at the AstraZeneca R&D site in Gothenburg. This dynamic event aims to build upon the success of the inaugural Therapeutic Oligonucleotides meeting and the well-regarded Advances in Cell-Based Assays in Drug Discovery. Esteemed scientists from academia, industry, and the vendor community will convene to explore the discovery, validation, and targeting of drug candidates using antisense oligonucleotides (ASOs) and siRNA. Our ambition is to establish an open-access meeting that fosters an inspiring environment for networking, encouraging collaboration between biologists and chemists across diverse research areas.

 

Oligonucleotide-based drugs, including ASOs and siRNAs, are already significantly impacting patients’ lives. The conference will delve into the nature of drug targets amenable to modulation by oligonucleotides, while comparing the advantages and limitations of these modalities with other drug types. Recent advancements in broadening their application, including innovative approaches to ensure their safety and efficacy, as well as the use of targeted delivery to reach disease-relevant tissues, will be covered. Success stories in bringing therapeutic oligonucleotides to the clinic will also be shared. The scientific sessions over two days will cover the following key areas detailed in the track information below.

Track Information

Day 1 – Wednesday 14th May

Auditorium 1

Target identification and validation

Track Chairs: David Gilot (AstraZeneca)

A successful therapeutic oligonucleotide project begins with identifying the right target and subsequently validating the biological hypothesis. In this track, we will explore how to tackle previously inaccessible targets and non-coding regions of the genome, enabled by recent advances in omics and computational biology (AI and machine learning).

 

Auditorium 2

Safety and efficacy advancements

Track Chairs: Hilary Brooks (Evotec)

This track explores how new fundamental mechanistic insights can improve clinical safety and efficacy. We will see how a basic understanding of RNA interference mechanisms and off-target activity can enable improved design tools. We will discuss progress in oligonucleotide pharmacokinetics and immunogenicity.

Day 2 – Thursday 15th May

Auditorium 1

Expanding cell – and tissue targeting

Track Chairs: Pär Matsson (University of Gothenburg) & Ulrik Lytt Rahbek (Novo Nordisk)

Delivering therapeutic oligonucleotides to tissues beyond the liver poses a significant challenge. This track will explore recent advancements in chemistry that enable the specific targeting of individual cell types or tissues. We will focus on innovative strategies for reaching extrahepatic tissues and subcellular delivery mechanisms such as endosomal escape.
Auditorium 2

Towards clinical success

Track Chairs: Anna Granqvist (Ribocure Pharmaceuticals) & Linda Sundström (AstraZeneca)

This session will bring together all aspects from the previous tracks and feature recent success stories of drugging previously undruggable targets. Academic and industrial perspectives on moving therapeutic oligonucleotides into the clinic and to patients will be shared, including various clinical challenges and regulatory perspectives.

Science Committee

Conference Directors

Fredrik Edfeldt

AstraZeneca

David Gilot

AstraZeneca

Linda Sundström

AstraZeneca

Karl-Johan Leuchowius

AstraZeneca

Ulrik Lytt Rahbek

Novo Nordisk

Pär Matsson

Saman Honarnejad

Evotec

Speakers

More details coming soon.

Activities

Each year Research & Innovation 2025 recognises outstanding contributions to science and innovation through our awards. Whether you’re an early career professional or part of an innovative start-up, we’re offering you the opportunity to celebrate your research or technology with the ELRIG community.

Awards available at this conference: 

  • Early Career Professional Best Poster Award

ECP Poster Award

The Early Career Professional Poster Award recognises the research and fresh ideas that the next generation of scientists bring to drug discovery.

Posters are judged on relevance, innovation, impact, and presentation quality, with the winner receiving:

  • £250 (which you can keep, donate to your lab, or give to charity).
  • A prestigious glass trophy.
  • Industry exposure & networking opportunities.

We define an ECP as an undergrad, postgrad (including PhD), or someone early in their career.

If you’re interested in applying for this award, please register for this conference and follow the instructions in your confirmation email.

Exhibitors

Floor plan and exhibitor list coming soon.

Posters

Discover numerous posters and innovative research from across the drug discovery community, aligned to our track themes. Hear from our Flash Poster Presenters and find out who has won the coveted Early Career Professional Poster Award!

PLEASE NOTE: Only one poster can be submitted per delegate. We only need your title and abstract, you do not need to upload your PDF. Also only Early Career Posters will be considered for a flash presentation at this event.

 

How to submit a poster

To submit a poster application you must first register for Research & Innovation 2025. A link to the poster portal will be available in your registration confirmation email. The poster abstract submitted must not exceed 300 words.

PLEASE NOTE: Only one poster can be submitted per delegate, we only need your title and abstract, you do not need to upload your PDF and only Early Career Posters will be considered for a flash presentation at this event.

Poster deadlines

  • Flash poster presentations are open to ECPs only – please submit your title and abstract by 13th April
  • to be considered for general display – upload your title and abstract by 27th April

We have limited space at site and late entries will not be accepted.

If you have any questions regarding your submission, please contact events@elrig.org

    Poster acceptance

    The author will be held responsible for false statements, the scientific judging panel will ensure the poster is relevant to the event content. Successful poster applications will be notified via email and the poster display number will be given approximately two weeks before the event.

    Flash Poster Acceptance 

    If your poster is chosen for a Flash Poster presentation, you will need to prepare a PowerPoint presentation to last no more than 5 minutes. The scientific judging panel will review the posters submitted for Flash poster presentations and if successful you will receive confirmation from the ELRIG Team two weeks prior to the event.

    During the event

    Your poster should be displayed for the duration of the full event.

    A board will be available with your poster number and Velcro strips to affix your poster (your poster must be A0 portrait).

    Poster sessions will take place during the late afternoon networking session on Day 1, and in the lunch refreshment break on Day 2.  You will be expected to be at your poster during these times to answer questions from delegates.

    All posters will need to be collected at the end of the event and removed from site; any posters left at the end of the event will be disposed of.

    ECP Poster Award

    ECP Poster Award

    The Early Career Professional Poster Award celebrates the fresh ideas and groundbreaking research shaping the future of drug discovery. The posters will be judged during Research & Innovation 2025 based on its relevance, innovation and impact. You will not need to be at your poster during judging. 

    If you’re an undergrad, postgrad (including PhD), or early in your career*, this is your chance to showcase your work and get the recognition you deserve.

    The winner will receive:

    • £250 (which you can keep, donate to your lab, or give to charity).
    • A prestigious glass trophy.
    • Industry exposure & networking opportunities.

    The prize is awarded during the opening session on day 2 of the event.

    To apply for this award, please register for Research & Innovation 2025. A link to the Poster Portal will be available in your confirmation email where you can submit a 300 word poster abstract.

    *Career breaks will be recognised, as will individuals whose career has spanned a break due to caring responsibilities or personal circumstances.

    During registration you will be asked if you identify as an ECP – An Early Career Professional (ECP) can be a student in higher education undertaking an undergraduate or postgraduate degree (including PhD), or within 5 years of finishing higher education and starting their career in life sciences and drug discovery.

    Venue & Accommodation

    AstraZeneca R&D Molndal
    PGN Conference Center
    Pepparedsleden 5
    S-431 53 Mölndal
    Sweden

    Plan your journey in advance.

     

    Book your accommodation with ELRIG’s Registration & Accommodation Partner MICE Concierge Ltd.

    The event room blocks represent your best value and most local hotels for the event. We understand there is a wide choice of options so if you don’t want to use the event room blocks we have partnered with Booking.com to give you access to the widest choice of hotels. Compare prices and see the widest choice with Booking.com.

    ELRIG is only able to provide suggestions on how delegates may travel to or places they may stay at, to attend its events. However, ELRIG cannot recommend nor endorse any of the travel choices nor hotels that attendees make and is not liable for any of the services that its delegates procure.

    AstraZeneca Site Tour

    Book your Amazing Journey AstraZeneca Site Tour on the registration form.

    On this guided tour you get to learn a little about AstraZenecas’s history, how they work with sustainability, how their scientists are working to find new medicines and what happens to the old medicines. You also get to hear the sound of a heart attack, and see how different diseases affect different parts of the world.

    Resources

    Social Media

    Download our useful social media images to share that you’ll be attending Therapeutic Oligos 2025 with your network.

    Sponsorship Opportunites

    We have several sponsorship opportunities available to exhibitors that can provide a wide range of new and exciting benefits for your organisation. We are also happy to discuss a tailored package to suit your budget. 

    Or visit our interactive floorplan to view available exhibitor spaces and book your booth at this conference.

    FAQs

    Are ELRIG events really FREE to attend?

    Yes ELRIG events are FREE to attend.

    We are a not-for-profit organisation hosting events for the drug discovery community. We believe that access to high quality science should be accessible to all. Find out more here.

    We’re grateful for the support from our exhibitors who help us cover the costs of our events from sponsorship and stand sales. If you come to our events, please take the time to visit our exhibition and meet our exhibitors.

    Or if you’re interested in exhibiting at an event, check out our sponsorship page.

    How do I change / cancel my registration?

    As a non-profit organisation, we aim to reduce food waste, and your cancellation helps support our sustainability efforts.

    If your circumstances change and you can no longer attend, please cancel your ticket. Your confirmation email includes a link to the cancellation site.

    Delegates: What do I need to bring with me?

    Please save your ticket to your smart device or print a copy. Upon arrival at the venue visit the ELRIG registration and scan the QR Code. Your badge will be automatically printed. If you forget or lose your QR Code you can enter your email address to print your badge.

    Refreshments will be provided, please bring your own reusable cups to help us reduce plastic waste at our events.

    Can I register on arrival?

    Yes you can. We would prefer that register before the event but if you have not, you can register at the ELRIG registration desk. 

    How do I cancel my registration if I cannot come?

    ELRIG events are often sold out and we are unable to cater to drop-ins. If you haven’t pre-registered we may be unable to let you in.

    Corporate Sponsors

    Become an exhibitor or sponsor